Read the article here.
According to UW CSE professor Martin Tompa: “Karlin was one of the pioneers who applied mathematics and statistical models to problems in biological sequence analysis. He worked in this field for the last 20 years or so. He wrote many important papers, but probably the most influential was a series of papers with Stephen Altschul in the early 1990s laying out the statistical foundation for BLAST, the most important piece of software in computational biology. Their work is known as the Karlin-Altschul Theory and is taught in many computational biology courses.”
Karlin was a member of the American Academy of Arts and Sciences and the National Academy of Sciences, and was awarded the National Medal of Science in 1989. He was the author of 10 books and more than 450 articles.
Earlier article from Stanford News Service here.